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Observe Closely (one)pentobarbital will lower the level or outcome of buprenorphine subdermal implant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Keep an eye on patients by now on buprenorphine subdermal implant who need freshly-initiated therapy with CYP3A4 inducer for signs and signs or symptom